Lewis-Roberts, 36, made his Sale debut during the Premiership-winning season in 2006 but has been forced to retire due to a knee injury that he picked up against Bristol last October.
A veteran of over 200 games, Lewis-Roberts has been one of the leading forwards in the Northern Hemisphere since making his debut against Newcastle Falcons, playing one game for Wales against Canada in 2008.
He also spent 12 months in France with Toulon under Philippe Saint-Andre in 2012-2103 before returning to Sharks.
Lewis-Roberts told the club website: “It’s sad that I have had to admit defeat to this knee injury.
“I was enjoying my rugby as I always did in the game at Bristol and I made a tackle which caused the damage. ”
Director of Rugby Steve Diamond added: “What a great servant Eifion has been for the club.
“He will be remembered for the 100% effort he put in each and every game. We are delighted that he will be attending all our home games as an ambassador of the club.”
Wasps v Sale Sharks (Sat)
Sale Sharks have named their side to take on Wasps at the Ricoh Arena on Saturday, kick off 3pm.
Steve Diamond hands full debuts to Josh Strauss, Faf de Klerk and Jono Ross with Alex Tarus on the bench – he will also make his debut if he takes the field.
Marc Jones and Will Cliff are also named on the bench having rejoined the club in the close season.
Sale Sharks: Mike Haley, Denny Solomona, Will Addison, Sam James, Byron McGuigan, AJ MacGinty, Faf de Klerk, Ross Harrison, Rob Webber, Halani Aulika, Bryan Evans, Josh Beaumont, Jono Ross, Ben Curry, Josh Strauss